Hair Loss and Hair Loss Treatment

Cutis. 2001 Jul;68(1):35-40

Management of male pattern hair loss.

Sinclair RD.
Department of Dermatology, St. Vincent's Hospital, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia. sinclair@svhm.org.au

The management of androgenetic alopecia (AGA) has been materially altered by the availability of the 5 alpha-reductase type 2 inhibitor, finasteride. Nevertheless, this agent is only one component of successful management, and an understanding of the role of camouflage agents, surgical options, and other medical treatments is important. Because no treatment completely reverses baldness, it is important to communicate the limitations of each modality to the patient so that he has appropriate expectations of the outcome of any intervention. Patient counseling and support are also often relevant.

Hair loss and hair loss treatment

Int J Radiat Oncol Biol Phys1984;10:233

In vivo radioprotective activities of diethyldithiocarbamate.
Milas L,

...Protection was significant against hair loss and leg contractures; PFs produced by 1000 mg/kg DDC were 1.44 and 1.38-1.51, respectively. Jejunum was protected by 400 mg/kg DDC (PF = 1.2), but not by 1000 mg/kg. The opposite was observed with testis: 1000 mg/kg was protective (PF = 1.2), but not 400 mg/kg. DDC also protected the FSa tumor, either as lung micrometastases or as a solitary tumor in the leg. Both 400 mg/kg and 1000 mg/kg DDC protected 4 day-old micrometastases by a PF of approximately 1.1. DDC at a dose of 1000 mg/kg protected 8 mm leg tumors by a PF of 1.24 at the TCD50 level. Therefore, DDC protected both normal tissues and FSA, but the degree of protection varied greatly. A therapeutic gain was achieved in some instances.

edited for hair loss treatment blog

Hairloss treatment blogs

blog.gohair.com/blog

a.gohair.com/blog

http://gohair.com/blog/index.php

http://www.drugscom.com/index.php

http://www.skindrugs.com/b2e/index.php

Cell Stem Cell. 2009 Jul 2;5(1):6-8.

Stem cell aging and aberrant differentiation within the niche.
Choi J, Artandi S.

Comment on:

Cell. 2009 Jun 12;137:1088

Stem cells age, but the underlying mechanisms remain unclear. In a recent issue of Cell, Inomata and colleagues (2009) show that DNA damage, a prime suspect in stem cell aging, causes hair graying and loss of melanocyte stem cells by inducing premature differentiation, without inducing apoptosis or senescence.

Curr Drug Targets. 2009;10:950

Modiefied and edited for use in hair loss treatment blog

Drug targeting through pilosebaceous route.
Chourasia R, Jain SK.

Local skin targeting is of interest for the pharmaceutical and the cosmetic industry. A topically applied substance has basically three possibilities to penetrate into the skin: transcellular, intercellular, and follicular. The transfollicular path has been largely ignored because hair follicles constitute only 0.1% of the total skin. The hair follicle is a skin appendage with a complex structure containing many cell types that produce highly specialised proteins. The hair follicle is in a continuous cycle of loss and regrowth: anagen is the hair regrowth phase, catagen the involution phase and telogen is the resting and hair loss phase. Nonetheless, the hair follicle has great potential for skin and hair loss treatment, owing to its deep extension into the dermis and thus provides much deeper penetration and absorption of compounds beneath the skin than seen with the transdermal route. In the case of skin diseases and of cosmetic products, delivery to sweat glands or to the pilosebaceous unit is essential for the effectiveness of the drug. Increased accumulation in the pilosebaceous unit could treat hair loss , acne and skin cancer more efficiently and improve the effect of cosmetic substances and nutrients. snip....

Int J Cosmet Sci. 2006 Oct;28(5):343-7.Links
Caffeine improves barrier function in male skin.Brandner JM, Behne MJ, Huesing B, Moll I.
Department of Dermatology and Venerology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.

The influence of androgens, especially testosterone and its effector dihydrotestosterone, results in a constitutive disadvantage for male skin, e.g. reduced viability of hair at the scalp and reduced epidermal permeability barrier repair capacity. Dihydrotestosterone can act, among others, as an adenyl cyclase inhibitor. Caffeine on the other hand is an inexpensive and (in regular doses) harmless substance used in various cosmetic products, which can act as a phosphodiesterase inhibitor. To prove the hypothesis that caffeine as a phosphodiesterase inhibitor is able to override testosterone-induced effects on barrier function, we performed a double-blind placebo controlled study with healthy volunteers. In this study, 0.5% caffeine in a hydroxyethylcellulose gel preparation (HEC) was applied on one forearm, HEC without caffeine on the other forearm of male and female volunteers for 7 days and transepidermal water loss (TEWL) was measured before and at the end of the treatment period. Basal TEWL did not differ significantly between male and female subjects but the application of caffeine significantly reduced TEWL in male skin compared with female skin. We conclude that caffeine is beneficial for barrier function in male skin.

Hair Loss and Hair Loss treatment